pentobarbital will minimize the level or impact of celecoxib by influencing hepatic enzyme CYP2C9/10 metabolism. Small/Importance Not known.

Caution when discontinuing CYP3A4 inducers that happen to be coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of hydrocodone might raise and may end up in potentially deadly respiratory melancholy.

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Elderly or debilitated people may well respond to barbiturates with marked melancholy, pleasure, and confusion; in some people, barbiturates consistently deliver excitement in lieu of melancholy

pentobarbital will reduce the level or influence of bexarotene by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.

pentobarbital will lower the extent or impact of lumacaftor/ivacaftor by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.

pentobarbital increases toxicity of buprenorphine, long-performing injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants improves danger of adverse reactions including overdose, respiratory depression, and Loss of life. Cessation of benzodiazepines or other CNS depressants is desired normally.

pentobarbital will lessen the level or effect of etravirine by impacting hepatic enzyme CYP2C9/ten metabolism. Use Warning/Check.

buprenorphine transdermal and pentobarbital both equally maximize sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternate procedure check here solutions are inadequate

Untimely infants are significantly liable to the depressant consequences of barbiturates; if barbiturates are made use of for the duration of labor and shipping, resuscitation products needs to be available

pentobarbital will reduce the level or outcome of docetaxel by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unidentified.

Contraindicated (one)pentobarbital will decrease the level or effect of naloxegol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Utilization of naloxegol with powerful CYP3A4 inducers is just not advisable

pentobarbital will minimize the level or result of triazolam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.

pentobarbital will lessen the extent or outcome of voriconazole by influencing hepatic enzyme CYP2C9/10 metabolism. Small/Significance Unfamiliar.